Always using the Latest Tweets (chronological) timeline - automatically switches you back when Twitter decides they'd rather you were on the "Home" (algorithmic) timeline because "engagement"
Removing retweets from your timeline
Removing sidebar content (Trends, Who to follow, sidefooter)
Removing some less-used links from the primary nav (Explore, Bookmarks, Links)
Using the site's base font size and normal font weight in the primary nav to make it less distracting (using your selected font size from the Display / Customize your view dialog)
These features all default to enabled and can be configured by editing the config object at the top of the script.